Domperidone Syrup

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Therapeutic Indication

Nausea and vomiting
Abdominal discomfort associated with dyspepsia
Delayed gastric emptying
Gastric motility disorders
Indigestion and bloating
Gastroesophageal reflux symptoms
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Domperidone

Syrup

Domperidone Syrup is an antiemetic and prokinetic formulation used to relieve nausea, vomiting, bloating, and gastric discomfort associated with delayed gastric emptying. It works by enhancing gastrointestinal motility and accelerating stomach emptying, thereby improving digestion and reducing symptoms such as fullness, reflux, and indigestion.
The formulation is commonly used in children and adults for the management of nausea and vomiting caused by gastrointestinal disorders, infections, medications, or digestive disturbances. It also helps relieve abdominal discomfort associated with gastric stasis and reflux-related symptoms.

Speciality Gastroenterology
Tags Antiemetic | Prokinetic Agent | Digestive Care | Gastric Motility Support
Strength
  • Domperidone – 1 mg / ml ( approx. 20 drops )
Packing Size
  • 30 ml Bottle

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Mechanism

Domperidone works by blocking dopamine (D2) receptors in the gastrointestinal tract and chemoreceptor trigger zone. This enhances gastric motility, accelerates stomach emptying, and helps prevent nausea and vomiting.

Benefits

  • Helps control nausea and vomiting
  • Relieves reflux-associated discomfort
  • Supports better digestion
  • Reduces bloating and fullness
  • Improves gastric emptying

Side Effects

  • Dry Mouth
  • Headache

Pharmacokinetics

  • Absorption: Rapid, low bioavailability (~15%).
  • Distribution: Highly protein bound (~91–93%).
  • Metabolism: Extensive hepatic via CYP3A4.
  • Excretion: Mainly feces (66%), urine (31%).
  • Half‑life: ~7–10 hours

Contraindication

  • Hypersensitivity to Domperidone
  • Gastrointestinal obstruction or bleeding
  • Severe hepatic impairment
  • Prolactin-releasing pituitary tumor (prolactinoma)

Dosage

  • As directed by the physician.

DRUG INTERACTIONS

  • Antifungal agents and macrolide antibiotics: May increase Domperidone levels
  • Antacids and antisecretory agents: May reduce effectiveness if taken together
  • QT-prolonging drugs: Increased risk of cardiac arrhythmias

Warning and Precautions

    This has been prescribed for the patient's specific condition. It may be dangerous to any other person.

  • Use cautiously in patients with liver disorders
  • Not recommended in patients with known cardiac rhythm disorders
  • Use under medical supervision in children
  • Do not exceed recommended dose
  • Store in a cool, dry place away from direct sunlight
  • Keep out of reach of children

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.